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Advanced Workshop Faculty Members
 LEON AARONS
is a Professor of Pharmacometrics in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
Research:
Population pharmacokinetics (PK) and pharmacodynamics (PD) aims to investigate and quantify PK/PD differences between patients. Population PK/PD is a modelling discipline and we use a variety of Maximum Likelihood and Bayesian techniques to perform the modelling. Current therapeutic applications include malaria, paediatrics, anti-inflammatories and anti-cancer agents. Computer aided clinical trial design (CATD) builds on population modelling and is a model based technique in which future clinical trials are designed based on the current state of knowledge using stochastic simulation techniques. The work is carried out within CAPKR. The methodology has been applied to an anti-migraine drug. The use of optimal design techniques is an alternative to CATD and aims to minimise parameter estimation error using various information criteria. Both frequentist and Bayesian methods are being applied. This work is also being carried out in CAPKR and we are currently working on both the methodology and developing software. Leon is co-editor of the Journal of Pharmacokinetics and Pharmacodynamics and executive editor
of the British Journal of Clinical Pharmacology.
| Dennis Fisher
is the President of the P Less Than Company, a
consultancy company. He assists pharma companies with clinical and regulatory strategies and conducts pharmacokinetic/pharmacodynamic analyses. Before year 2000, he was a Professor of Anesthesia and Pediatrics at the University of California, San Francisco and an Editor of the
journal Anesthesiology.
| Mats Karlsson
is Professor of Pharmacometrics at the Faculty of Pharmacy, Uppsala University, Sweden. Since 1994, his research group has focused on methodological aspects of nonlinear mixed effects model building and applied PK/PD modeling.
| Jaap Mandema
is President and Chief Scientific Officer of Quantitative Solutions, a consultancy company. Before joining Quantitative Solutions, he was Chief Scientific Officer at Pharsight a company that provides software and consulting services to the pharmaceutical industry to improve efficiency of drug development. His research interests are application of modeling and simulation to optimize drug treatment, trial designs, and drug development decision-making.
| France Mentre
is Professor of Biostatistics at the University Hospital Bichat Claude Bernard (Paris 7). She heads an INSERM research team on Methods and Models for therapeutic assessment in chronic diseases. She has worked on development and application of methods for nonlinear mixedeffects models in pharmacokinetics and pharmacodynamics for more than 20 years
| Steven Shafer
is Professor of Anesthesia at Stanford
University and Adjunct Professor of Biopharmaceutical Science at UCSF. His research interests are in mathematical modeling of intravenous and inhalational anesthetics, including population PK/PD, drug interactions, computer controlled drug administration, quantitative measures of
anesthetic drug effect, and model-based pharmaceutical development.
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